Explore: The Journal of Science and Healing
Volume 3, Issue 2 , Pages 98-109 , March 2007

Efficacy of a Complex Homeopathic Medication (Sinfrontal) in Patients with Acute Maxillary Sinusitis: A Prospective, Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial

  • Dmitriy I. Zabolotnyi, PhD, MD

      Affiliations

    • Research Institute for Ear, Nose, and Throat Diseases, Director ENT Diseases at the Ministry of Health, Kiev, Ukraine
    • ,
  • Kyra C. Kneis

      Affiliations

    • Health Research Services Ltd, Kiev, Ukraine
    • ,
  • Andy Richardson, PhD

      Affiliations

    • Health Research Services Ltd, Berkshire, England
    • ,
  • Reinhard Rettenberger, PhD

      Affiliations

    • Chemisch-Pharmazeutische Fabrik Goeppingen, Carl Mueller, Apotheker, GmbH u. Co. KG, Goeppingen, Germany
    • ,
  • Marianne Heger, MD

      Affiliations

    • Health Research Services Ltd, St Leon-Rot, Germany
    • Marianne Heger passed away on August 24, 2005 before the results of her medical and scientific contributions to this paper could be realized. Her fellow authors pay tribute to the leadership, guidance, and enthusiasm she contributed that was critical to the successful completion of these studies.
    • ,
  • Marietta Kaszkin-Bettag, PhD

      Affiliations

    • Health Research Services Ltd, St Leon-Rot, Germany
    • Corresponding Author InformationCorresponding Author. Address: Opelstrasse 8a, 68789 St. Leon-Rot, Germany
    • ,
  • Peter W. Heger

      Affiliations

    • Health Research Services Ltd, St Leon-Rot, Germany

References 

  1. Benninger MS, Sedory Holzer SE, Lau J. Diagnosis and treatment of uncomplicated acute bacterial rhinosinusitis: summary of the Agency for Health Care Policy and Research evidence-based report. Otolaryngol Head Neck Surg. 2000;22:1–7
  2. DeRaps PK. The evaluation of the client with acute bacterial rhinosinusitis. Lippincotts Prim Care Pract. 2000;4:490–497
  3. McCaig LF, Hughes JM. Trends in antimicrobial drug prescribing among office-based physicians in the United States. JAMA. 1995;273:408–414
  4. Agency for Health Care Policy and Research. Diagnosis and Treatment of Acute Bacterial Rhinosinusitis. Rockville, Md: Agency for Health Care Policy and Research; 1999;
  5. Gwaltney JM. Management of acute community-acquired rhinosinusitis. APUA Newsletter 14(1):1-5. Available at: http://www.tufts.edu/med/apua/Newsletter/14_1a.html. Accessed March 28, 2006.
  6. Bergogne-Berezin E. Controlling acute bacterial maxillary sinusitis. Expert Opin Pharmacother. 2002;3:1471–1479
  7. Winther B, Gwaltney JM. Acute and chronic sinusitis. In:  Pennington J editors. Respiratory Infections: Diagnosis and Management. 3rd ed.. New York, NY: Raven Press; 1994;p. 125–136
  8. Chow AW. Acute sinusitis: current status of etiologies, diagnosis, and treatment. Curr Clin Top Infect Dis. 2001;21:31–63
  9. Little DR, Mann BL, Sherk DW. Factors influencing the clinical diagnosis of sinusitis. J Fam Pract. 1998;46:147–152
  10. Lindbaek M, Hjortdahl P. The clinical diagnosis of acute purulent sinusitis in general practice–a review. Br J Gen Pract. 2002;52:491–495
  11. Low DE, Desrosiers M, McSherry J, et al. A practical guide for the diagnosis and treatment of acute sinusitis. Can Med Assoc J. 1997;156(6 suppl):S1–S14
  12. Varonen H, Mäkelä M, Savolainen S. Comparison of ultrasound, radiography, and clinical examination in the diagnosis of acute maxillary sinusitis: a systematic review. J Clin Epidemiol. 2000;53:940–948
  13. van Buchem FL, Knottnerus JA, Schrijnemaekers VJJ, Peeters MF. Primary-care-based randomised placebo-controlled trial of antibiotic treatment in acute maxillary sinusitis. Lancet. 1997;349:683–687
  14. Arroll B. Antibiotics for upper respiratory tract infections: an overview of Cochrane reviews. Respir Med. 2005;99:255–261
  15. Dunbar LM. Current issues in the management of bacterial respiratory tract disease (The challenge of antibacterial resistance). Am J Med Sci. 2003;326:360–368
  16. Felmingham D, Grüneberg RN. The Alexander Project 1996-1997: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections. J Antimicrob Chemother. 2000;45:191–203
  17. Bax R, Bywater R, Cornaglia G, et al. Surveillance of antimicrobial resistance–what, how and whether?. Clin Microbiol Infect. 2001;7:316–325
  18. Heidbreder D, Gerster G, Gracza E. Sinusitis: Klinische Prüfung verschiedener homöopathischer Medikamente in unterschiedlichen Potenzen. Therapeutikon. 1988;2:701–706
  19. Heidbreder D, Gerster G, Gracza E. Nutzen sekretolytischer Therapie bei akuter und chronischer Sinusitis. Therapiewoche. 1986;36:3537–3540
  20. Anwendungsbeobachtung mit Sinfrontal bei Sinusitis. Informationsbroschüre Fa. Müller Göppingen 1995. Chemisch-Pharmazeutische Fabrik Goeppingen, Carl Mueller, Apotheker, GmbH u. Co. KG, 73033 Goeppingen, Germany.
  21. Sinfrontal Bericht über eine Anwendungsbeobachtung in der Praxis bei 109 Ärzten und 725 Patienten. Informationsbroschüre Fa. Müller Göppingen 1990. Chemisch-Pharmazeutische Fabrik Goeppingen, Carl Mueller, Apotheker, GmbH u. Co. KG, 73033 Goeppingen, Germany.
  22. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998;280:1569–1575
  23. Melchart D, Linde K, Fischer P, Kaesmayr J. Echinacea for preventing and treating the common cold (Cochrane Review). In: The Cochrane Library. 2001;Issue 1.
  24. Piccirillo JF, Merritt MG, Richards ML. Psychometric and clinimetric validity of the 20-Item Sino-Nasal Outcome Test (SNOT-20). Otolaryngol Head Neck Surg. 2002;126:41–47
  25. Stein KD, Jacobsen PB. Multidimensional Fatigue Symptom Inventory. Tampa, Fla: Moffitt Cancer Center and University of South Florida; 1998;
  26. Stanford Sleepiness Scale. Available at: http://www.stanford.edu/∼dement/sss.html. Accessed February 14, 2007.
  27. Görtelmeyer R. Schlaffragebogen A und B In: Internationale Skalen für Psychiatrie. Weinheim, Germany: Beltz Test GmbH; 1986;p. 125–135CIPS

PII: S1550-8307(06)00563-5

doi: 10.1016/j.explore.2006.12.007

Explore: The Journal of Science and Healing
Volume 3, Issue 2 , Pages 98-109 , March 2007

Article Tools

* Image Usage & Resolution