Explore: The Journal of Science and Healing
Volume 5, Issue 2 , Pages 97-103 , March 2009

Unique Aspects of Herbal Whole System Research

  • Suzanna M. Zick, ND, MPH

      Affiliations

    • Department of Family Medicine, University of Michigan, Ann Arbor, MI
    • Corresponding Author InformationCorresponding Author. Address: 715 E. Huron St, Suite 2E, Ann Arbor, MI, 48104
  • ,
  • Herbert Schwabl, PhD

      Affiliations

    • Padma Inc., Schwerzenbach, Switzerland
  • ,
  • Andrew Flower, LAc, Dip CHM

      Affiliations

    • Department of Primary Care, University of Southampton, UK
  • ,
  • Bibhas Chakraborty, PhD

      Affiliations

    • Department of Statistics, University of Michigan, Ann Arbor, MI
  • ,
  • Kristine Hirschkorn, PhD

      Affiliations

    • Faculty of Pharmacy, University of Toronto, Toronto, Canada

References 

  1. Ritenbaugh C, Verhoef M, Fleishman S, Boon H, Leis A. Whole systems research: a discipline for studying complementary and alternative medicine. Altern Ther Health Med. 2003;9(4):32–36
  2. Elder C, Aickin M, Bell IR, et al. Methodological challenges in whole systems research. J Altern Complement Med. 2006;12:843–850
  3. Herman PM, Sherman KJ, Erro JH, Cherkin DC, Milliman B, Adams LA. A method for describing and evaluating naturopathic whole practice. Altern Ther Health Med. 2006;12(4):20–28
  4. Schnyer RN, Allen JJ. Bridging the gap in complementary and alternative medicine research: manualization as a means of promoting standardization and flexibility of treatment in clinical trials of acupuncture. J Altern Complement Med. 2002;8:623–634
  5. AHG Professional Membership. http://www.americanherbalistsguild.com/membership/professionalAccessed June 19, 2007
  6. Becoming a Medical Herbalist. http://www.nimh.org.uk/training.htmlAccessed June 19, 2007
  7. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH harmonised tripartite guideline, guideline for good clinical practice, E6(R1). http://www.ich.org/LOB/media/MEDIA482.pdfAccessed June 1, 2008
  8. Brennan TA, Rothman DJ, Blank L, et al. Health industry practices that create conflicts of interest: a policy proposal for academic medical centers. JAMA. 2006;295:429–433
  9. Raftery J, Bryant J, Powell J, Kerr C, Hawker S. Payment to healthcare professionals for patient recruitment to trials: systematic review and qualitative study. Health Technol Assess. 2008;12(10):1–128
  10. Lewith GT, Jonas W, Walach H. Clinical Research in Complementary Therapies. Edinburgh, UK: Churchill Livingstone; 2002;
  11. Zick SM, Blume A, Normolle D, Ruffin M. Challenges in herbal research: a randomized clinical trial to assess blinding with ginger. Complement Ther Med. 2005;13:101–106
  12. Bensoussan A, Talley NJ, Hing M, Menzies R, Guo A, Ngu M. Treatment of irritable bowel syndrome with Chinese herbal medicine: a randomized controlled trial. JAMA. 1998;280:1585–1589
  13. Sheehan MP, Atherton DJ. A controlled trial of traditional Chinese medicinal plants in widespread non-exudative atopic eczema. Br J Dermatol. 1992;126:179–184
  14. Dube A, Manthata LN, Syce JA. The design and evaluation of placebo material for crude herbals: Artemisia afra herb as a model. Phytother Res. 2007;21:448–451
  15. Dennis C. The connective model: a new therapeutic study describes the nature of the patient-herbalist relationship. Can J Herb. 2007;28:3–14
  16. Elliotson S. The herbal forum: compound formulas or simples? (Which do you prefer and why?). Can J Herb. 2006;27:29
  17. Holland P. Statistics and causal inference. J Amer Stat Assoc. 1986;81:945–970
  18. Medical Research Council. A framework for development and evaluation of RCTs for complex interventions to improve health. http://www.mrc.ac.uk/Utilities/Documentrecord/index.htm?d=MRC003372Accessed June 27, 2008
  19. Collins LM, Murphy SA, Nair VN, Strecher VJ. A strategy for optimizing and evaluating behavioral interventions. Ann Behav Med. 2005;30:65–73
  20. Byar D, Piantadosi S. Factorial designs for randomized clinical trials. Cancer Treatment Rep. 1985;69:1055–1063
  21. Nair V, Strecher V, Fagerlin A, et al. Screening experiments and fractional factorial designs for behavioral intervention research. Am J Public Health. 2008;
  22. Strecher V, McClure J, Alexander G, et al. Web-based smoking cessation components and tailoring depth: results of a randomized trial. Am J Prev Med. 2008;34:373–381

 This research has been partially supported by National Cancer Institute (NCI) grant P50 CA 101451 and K07 CA102592 awarded to Dr Zick; NIDA grants R21 DA 019800, P50 DA 10075, and K02 DA 15674 awarded to Dr Chakraborty; and CIHR personnel awarded to Dr Hirschkorn. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review or approval of the manuscript.

PII: S1550-8307(08)00382-0

doi: 10.1016/j.explore.2008.12.001

Explore: The Journal of Science and Healing
Volume 5, Issue 2 , Pages 97-103 , March 2009