Explore: The Journal of Science and Healing
Volume 6, Issue 1 , Pages 29-41 , January 2010

Top-Down and Bottom-Up Mechanisms in Mind-Body Medicine: Development of an Integrative Framework for Psychophysiological Research

  • Ann Gill Taylor, EdD, MS, RN, FAAN

      Affiliations

    • Center for the Study of Complementary and Alternative Therapies, School of Nursing, University of Virginia, Charlottesville, VA
    • Corresponding Author InformationCorresponding Author. Address:
    • ,
  • Lisa E. Goehler, PhD

      Affiliations

    • Center for the Study of Complementary and Alternative Therapies, School of Nursing, University of Virginia, Charlottesville, VA
    • ,
  • Daniel I. Galper, PhD

      Affiliations

    • American Psychological Association, Washington, DC
    • ,
  • Kim E. Innes, PhD

      Affiliations

    • Center for the Study of Complementary and Alternative Therapies, School of Nursing, University of Virginia, Charlottesville, VA
    • ,
  • Cheryl Bourguignon, PhD, RN

      Affiliations

    • Center for the Study of Complementary and Alternative Therapies, School of Nursing, University of Virginia, Charlottesville, VA

References 

  1. Astin JA, Shapiro SL, Eisenberg DM, Forys KL. Mind-body medicine: state of the science, implications for practice. J Am Board Fam Pract. 2003;16:131–147
  2. Carlson CR, Hoyle RH. Efficacy of abbreviated progressive muscle relaxation training: a quantitative review of behavioral medicine research. J Consult Clin Psychol. 1993;61:1059–1067
  3. Galper DI, Taylor AG, Cox DJ. Current status of mind-body interventions for vascular complications of diabetes. Fam Community Health. 2003;26:34–40
  4. Innes KE, Bourguignon C, Taylor AG. Risk indices associated with the insulin resistance syndrome, cardiovascular disease, and possible protection with yoga: a systematic review. J Am Board Fam Pract. 2005;18:491–519
  5. Innes KE, Vincent HK. The influence of yoga-based programs on risk profiles in adults with type 2 diabetes mellitus: a systematic review. Evid Based Complement Alternat Med. 2007;4:469–486
  6. Innes KE, Vincent HK, Taylor AG. Chronic stress and insulin resistance-related indices of cardiovascular disease risk, part I: neurophysiological responses and pathological sequelae. Altern Ther Health Med. 2007;13:46–52
  7. Jacobs GD. The physiology of mind-body interactions: the stress response and the relaxation response. [erratum appears in J Altern Complement Med. 2002;8:219] J Altern Complement Med. 2001;7(suppl 1):S83–S92
  8. Manber R, Allen JJ, Morris MM. Alternative treatments for depression: empirical support and relevance to women. J Clin Psychiatry. 2002;63:628–640
  9. Montgomery GH, DuHamel KN, Redd WH. A meta-analysis of hypnotically induced analgesia: how effective is hypnosis?. Int J Clin Exp Hypn. 2000;48:138–153
  10. Taylor AG, Galper DI, D'Huyvetter K, Bourguignon C, Lyon DE. Pain. In:  Spencer JW,  Jacobs JJ editor. Complementary and Alternative Medicine: an Evidenced-Based Approach. 2nd ed. St. Louis, Mo: Mosby, Inc; 2003;p. 311–408
  11. Lucini D, Covacci G, Milani R, Mela GS, Malliani A, Pagani M. A controlled study of the effects of mental relaxation on autonomic excitatory responses in healthy subjects. Psychosom Med. 1997;59:541–552
  12. Weber C, Arck P, Mazurek B, Klapp BF. Impact of a relaxation training on psychometric and immunologic parameters in tinnitus sufferers. J Psychosom Res. 2002;52:29–33
  13. Kiecolt-Glaser JK, Marucha PT, Atkinson C, Glaser R. Hypnosis as a modulator of cellular immune dysregulation during acute stress. J Consult Clin Psychol. 2001;69:674–682
  14. Wood GJ, Bughi S, Morrison J, Tanavoli S, Tanavoli S, Zadeh HH. Hypnosis, differential expression of cytokines by T-cell subsets, and the hypothalamo-pituitary-adrenal axis. Am J Clin Hypn. 2003;45:179–196
  15. Lutgendorf S, Logan H, Kirchner HL, et al. Effects of relaxation and stress on the capsaicin-induced local inflammatory response. Psychosom Med. 2000;62:524–534
  16. Zachariae R, Jorgensen MM, Egekvist H, Bjerring P. Skin reactions to histamine of healthy subjects after hypnotically induced emotions of sadness, anger, and happiness. Allergy. 2001;56:734–740
  17. Saydah SH, Eberhardt MS. Use of complementary and alternative medicine among adults with chronic diseases: United States 2002. J Altern Complement Med. 2006;12:805–812
  18. Eisenberg DM, Davis RB, Ettner SL, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998;280:1569–1575
  19. Cuellar N, Galper DI, Taylor AG, D'Huyvetter K, Miederhoff P, Stubbs P. Restless legs syndrome. J Altern Complement Med. 2004;10:422–423
  20. Owens JE, Taylor AG, Degood D. Complementary and alternative medicine and psychologic factors: toward an individual differences model of complementary and alternative medicine use and outcomes. J Altern Complement Med. 1999;5:529–541
  21. NIH Technology Assessment Panel on Integration of Behavioral and Relaxation Approaches into the Treatment of Chronic Pain and Insomnia. Integration of behavioral and relaxation approaches into the treatment of chronic pain and insomnia. JAMA. 1996;276:313–318
  22. Watkins AD. Contemporary context of complementary and alternative medicine: integrated mind-body medicine. In:  Micozzi MS editors. Fundamentals of Complementary and Alternative Medicine. New York, NY: Churchill Livingston; 1996;p. 49–63
  23. Barnes P, Powell-Griner E, McFann K, Nahin R. Complementary and Alternative Medicine Use among Adults: United States, 2002. CDC Advance Data Report #343. May 27, 2004 http://www.cdc.gov/nchs/data/ad/ad343.pdfAccessed July 26, 2008
  24. Bremner JD. Does Stress Damage the Brain? (Understanding Trauma-Related Disorders from a Mind-Body Perspective). New York, NY: WW Norton; 2002;
  25. Critchley HD, Mathias CJ, Dolan RJ. Neural activity in the human brain relating to uncertainty and arousal during anticipation. Neuron. 2001;29:537–545
  26. Fiero PL, Galper DI, Cox DJ, Phillips LH, Fryburg DA. Thermal biofeedback and lower extremity blood flow in adults with diabetes: is neuropathy a limiting factor?. Appl Psychophysiol Biofeedback. 2003;28:193–203
  27. Innes KE, Vincent HK, Taylor AG. Chronic stress and insulin resistance-related indices of cardiovascular disease risk, part 2: a potential role for mind-body therapies. [erratum appears in Altern Ther Health Med. 2007;13(6):15] Altern Ther Health Med. 2007;13(5):44–51
  28. Menzies V, Taylor AG, Bourguignon C. Effects of guided imagery on outcomes of pain, functional status, and self-efficacy in persons diagnosed with fibromyalgia. J Altern Complement Med. 2006;12:23–30
  29. Menzies V, Taylor AG, Bourguignon C. Absorption: an individual difference to consider in mind-body interventions. J Holist Nurs. 2008;26:297–302
  30. Taibi DM, Bourguignon C. The role of complementary and alternative therapies in managing rheumatoid arthritis. Fam Community Health. 2003;26:41–52
  31. Taylor AG, Galper DI, Taylor P, et al. Effects of adjunctive Swedish massage and vibration therapy on short-term postoperative outcomes: a randomized, controlled trial. J Altern Complement Med. 2003;9:77–89
  32. Sternberg EM. The Balance Within: the Science Connecting Health and Emotions. New York, NY: WH Freeman; 2001;
  33. Benson H. The relaxation response: its subjective and objective historical precedents and physiology. Trends Neurosci. 1983;6:281–284
  34. Benson H, Klipper MZ. The Relaxation Response. New York, NY: HarperCollins; 2000;
  35. Benson H, Beary J, Carol MP. The relaxation response. Psychiatry. 1974;37:37–46
  36. Hoffman JW, Benson H, Arns PA, et al. Reduced sympathetic nervous system responsivity associated with the relaxation response. Science. 1982;215:190–192
  37. Porges SW. Cardiac vagal tone: a physiological index of stress. Neurosci Biobehav Rev. 1995;19:225–233
  38. Porges SW. The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol. 2001;42:123–146
  39. LeDoux JE. Synaptic Self: How Our Brains Become Who We Are. New York, NY: Viking; 2002;
  40. Zagon A. Does the vagus nerve mediate the sixth sense?. Trends Neurosci. 2001;24:671–673
  41. Goehler LE, Gaykema RP, Hansen MK, Anderson K, Maier SF, Watkins LR. Vagal immune-to-brain communication: a visceral chemosensory pathway. Auton Neurosci. 2000;85(1-3):49–59
  42. Thayer JF, Lane RD. A model of neurovisceral integration in emotion regulation and dysregulation. J Affect Disord. 2000;61:201–216
  43. Benarroch EE. Central Autonomic Network: Functional Organization and Clinical Correlations. Armonk, NY: Futura Publishing; 1997;
  44. Hilgard ER. Hypnotic Susceptibility. New York, NY: Harcourt, Brace & World; 1965;
  45. Hilgard ER. Divided Consciousness: Multiple Controls in Human Thought and Action. New York, NY: Wiley; 1977;
  46. Pribram KH. Brain and Perception: Holonomy and Structure in Figural Processing. Hillsdale, NJ: Lawrence Erlbaum Associates; 1991;
  47. Pribram KH, McGuinness D. Arousal, activation, and effort in the control of attention. Psychol Rev. 1975;82:116–149
  48. Crawford HJ. Brain dynamics and hypnosis: attentional and disattentional processes. Int J Clin Exp Hypn. 1994;42:204–232
  49. Crawford HJ. Cerebral brain dynamics of mental imagery: evidence and issues for hypnosis. In:  Kunzendorf RJ,  Spanos M,  Wallace B editor. Hypnosis and Imagination. Amityville, NY: Baywood Publishing; 1996;p. 253–283
  50. Crawford HJ, Brown AM, Moon CE. Sustained attentional and disattentional abilities: differences between low and highly hypnotizable persons. J Abnorm Psychol. 1993;102:534–543
  51. Crawford HJ, Gur RC, Skolnick B, Gur RE, Benson DM. Effects of hypnosis on regional cerebral blood flow during ischemic pain with and without suggested hypnotic analgesia. Int J Psychophysiol. 1993;15:181–195
  52. Craig AD. How do you feel? (Interoception: the sense of the physiological condition of the body). Nat Rev Neurosci. 2002;3:655–666
  53. Naliboff BD, Derbyshire SW, Munakata J, et al. Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation. Psychosom Med. 2001;63:365–375
  54. Pizzagalli D, Pascual-Marqui RD, Nitschke JB, et al. Anterior cingulate activity as a predictor of degree of treatment response in major depression: evidence from brain electrical tomography analysis. Am J Psychiatry. 2001;158:405–415
  55. Damasio AR. Descartes' Error: Emotion, Reason, and the Human Brain. New York, NY: Putnam; 1994;
  56. Damasio AR. The Feeling of What Happens: Body and Emotion in the Making of Consciousness. New York, NY: Harcourt Brace; 1999;
  57. Critchley HD, Mathias CJ, Dolan RJ. Neuroanatomical basis for first- and second-order representations of bodily states. Nat Neurosci. 2001;4:207–212
  58. Frith CD, Friston K, Liddle PF, Frackowiak RS. Willed action and the prefrontal cortex in man: a study with PET. Proc R Soc Lond B Bio Sci. 1991;244:241–246
  59. Spencer JW, Jacobs JJ. Complementary and Alternative Medicine: an Evidence-Based Approach. In: St. Louis, Mo: Mosby; 2003;p. 578
  60. Hugdahl K. Psychophysiology: The Mind-Body Perspective. Cambridge, Mass: Harvard University Press; 1995;
  61. Mayberg HS, Liotti M, Brannan SK, et al. Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry. 1999;156:675–682
  62. Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci. 2000;85(1-3):1–17
  63. Janig W. Neurobiology of visceral afferent neurons: neuroanatomy, functions, organ regulations and sensations. Biol Psychol. 1996;42(1-2):29–51
  64. Verberne AJ, Saita M, Sartor DM. Chemical stimulation of vagal afferent neurons and sympathetic vasomotor tone. Brain Res. Brain Res. Rev. 2003;41:288–305
  65. Critchley HD, Melmed RN, Featherstone E, Mathias CJ, Dolan RJ. Brain activity during biofeedback relaxation: a functional neuroimaging investigation. Brain. 2001;124(pt 5):1003–1012
  66. van den Bos W, McClure SM, Harris LT, Fiske ST, Cohen JD. Dissociating affective evaluation and social cognitive processes in the ventral medial prefrontal cortex. Cogn Affect Behav Neurosci. 2007;7:337–346
  67. Wong SW, Masse N, Kimmerly DS, Menon RS, Shoemaker JK. Ventral medial prefrontal cortex and cardiovagal control in conscious humans. Neuroimage. 2007;35:698–708
  68. Drevets WC. Prefrontal cortical-amygdalar metabolism in major depression. Ann N Y Acad Sci. 1999;877:614–637
  69. Haas HS, Schauenstein K. Neuroimmunomodulation via limbic structures–the neuroanatomy of psychoimmunology. Prog Neurobiol. 1997;51:195–222
  70. Van Eden CG, Buijs RM. Functional neuroanatomy of the prefrontal cortex: autonomic interactions. Prog Brain Res. 2000;126:49–62
  71. Gold PW, Chrousos GP. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol Psychiatry. 2002;7:254–275
  72. Janig W, Habler HJ. Specificity in the organization of the autonomic nervous system: a basis for precise neural regulation of homeostatic and protective body functions. Prog Brain Res. 2000;122:351–367
  73. Saper CB. The central autonomic nervous system: conscious visceral perception and autonomic pattern generation. Annu Rev Neurosci. 2002;25:433–469
  74. Beauregard M, Levesque J, Bourgouin P. Neural correlates of conscious self-regulation of emotion. J Neurosci. 2001;21:R165
  75. Buijs RM, Van Eden CG. The integration of stress by the hypothalamus, amygdala and prefrontal cortex: balance between the autonomic nervous system and the neuroendocrine system. Prog Brain Res. 2000;126:117–132
  76. Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci. 2001;24:167–202
  77. Sullivan RM, Gratton A. Prefrontal cortical regulation of hypothalamic-pituitary-adrenal function in the rat and implications for psychopathology: side matters. Psychoneuroendocrinology. 2002;27:99–114
  78. Arnsten AF. Stress impairs prefrontal cortical function in rats and monkeys: role of dopamine D1 and norepinephrine alpha-1 receptor mechanisms. Prog Brain Res. 2000;126:183–192
  79. Papousek I, Schulter G. Associations between EEG asymmetries and electrodermal lability in low vs. high depressive and anxious normal individuals. Int J Psychophysiol. 2001;41:105–117
  80. Davidson RJ, Pizzagalli D, Nitschke JB, Putnam K. Depression: perspectives from affective neuroscience. Annu Rev Psychol. 2002;53:545–574
  81. Gruzelier J, Clow A, Evans P, Lazar I, Walker L. Mind-body influences on immunity: lateralized control, stress, individual differences predictors, and prophylaxis. Ann N Y Acad Sci. 1998;851:487–494
  82. Pauli P, Wiedemann G, Nickola M. Pain sensitivity, cerebral laterality, and negative affect. Pain. 1999;80:359–364
  83. Wittling W. The right hemisphere and the human stress response. Acta Physiol Scand. 1997;640:55–59
  84. Wittling W, Block A, Schweiger E, Genzel S. Hemisphere asymmetry in sympathetic control of the human myocardium. Brain Cogn. 1998;38:17–35
  85. Bortolomasi M, Minelli A, Fuggetta G, et al. Long-lasting effects of high frequency repetitive transcranial magnetic stimulation in major depressed patients. Psychiatry Res. 2007;150:181–186
  86. Davidson RJ. Affective style, psychopathology, and resilience: brain mechanisms and plasticity. Am Psychol. 2000;55:1196–1214
  87. Jennings JR, Muldoon MF, Ryan CM, et al. Cerebral blood flow in hypertensive patients: an initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks. Hypertension. 1998;31:1216–1222
  88. Soufer R, Bremner JD, Arrighi JA, et al. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease. Proc Natl Acad Sci U S A. 1998;95:6454–6459
  89. Irani SR. A novel neurological mechanism to explain the adverse effect of depression on coronary artery disease. Med Hypotheses. 2005;64:284–287
  90. Williamson JW, McColl R, Mathews D, Ginsburg M, Mitchell JH. Activation of the insular cortex is affected by the intensity of exercise. J Appl Physiol. 1999;87:1213–1219
  91. Williamson JW, McColl R, Mathews D, Mitchell JH, Raven PB, Morgan WP. Brain activation by central command during actual and imagined handgrip under hypnosis. J Appl Physiol. 2002;92:1317–1324
  92. Critchley HD, Melmed RN, Featherstone E, Mathias CJ, Dolan RJ. Volitional control of autonomic arousal: a functional magnetic resonance study. Neuroimage. 2002;16:909–919
  93. Asada H, Fukuda Y, Tsunoda S, Yamaguchi M, Tonoike M. Frontal midline theta rhythms reflect alternative activation of prefrontal cortex and anterior cingulate cortex in humans. Neurosci Lett. 1999;274:29–32
  94. Rainville P, Hofbauer RK, Paus T, Duncan GH, Bushnell MC, Price DD. Cerebral mechanisms of hypnotic induction and suggestion. J Cogn Neurosci. 1999;11:110–125
  95. Capuron L, Pagnoni G, Demetrashvili M, et al. Anterior cingulate activation and error processing during interferon-alpha treatment. Biol Psychiatry. 2005;58:190–196
  96. Rosenkranz MA, Davidson RJ. Affective neural circuitry and mind-body influences in asthma. Neuroimage. 2009;47:972–980
  97. Hamani C, Mayberg H, Snyder B, Giacobbe P, Kennedy S, Lozano AM. Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targeting. J Neurosurg. 2009;1–7doi: 10.3171/2008.10. JNS08763
  98. Carr L, Iacoboni M, Dubeau MC, Mazziotta JC, Lenzi GL. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci U S A. 2003;100:5497–5502
  99. Labus JS, Naliboff BN, Fallon J, et al. Sex differences in brain activity during aversive visceral stimulation and its expectation in patients with chronic abdominal pain: a network analysis. Neuroimage. 2008;41:1032–1043
  100. Simmons A, Strigo I, Matthews SC, Paulus MP, Stein MB. Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biol Psychiatry. 2006;60:402–409
  101. El-Sheikh M. Parental drinking problems and children's adjustment: vagal regulation and emotional reactivity as pathways and moderators of risk. J Abnorm Psychol. 2001;110:499–515
  102. Cameron OG. Visceral Sensory Neuroscience: Interoception. New York, NY: Oxford University Press; 2002;
  103. Henry TR. Therapeutic mechanisms of vagus nerve stimulation. Neurology. 2002;59(6 suppl 4):S3–S14
  104. Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Pharmacol. 2006;147:232–240
  105. Emmert MH, Herman JP. Differential forebrain c-fos mRNA induction by ether inhalation and novelty: evidence for distinctive stress pathways. Brain Res. 1999;845:60–67
  106. Sawchenko PE, Li HY, Ericsson A. Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms. Prog Brain Res. 2000;122:61–78
  107. Lazarus RS. Stress and Emotion: A New Synthesis. New York, NY: Springer Publishing Co; 1999;
  108. Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry. 2000;157:683–694
  109. Lucini D, Mela GS, Malliani A, Pagani M. Impairment in cardiac autonomic regulation preceding arterial hypertension in humans: insights from spectral analysis of beat-by-beat cardiovascular variability. Circulation. 2002;106:2673–2679
  110. Hosoi T, Okuma Y, Nomura Y. Electrical stimulation of afferent vagus nerve induces IL-1beta expression in the brain and activates HPA axis. Am J Physiol. Regul Integr Comp Physiol. 2000;279:R141–R147
  111. McEwen BS. Sex, stress and the hippocampus: allostasis, allostatic load and the aging process. Neurobiol Aging. 2002;23:921–939
  112. McEwen BS. Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders. Ann N Y Acad Sci. 2004;1032:1–7
  113. Balu DT, Lucki I. Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology. Neurosci Biobehav Rev. 2009;33:232–252
  114. Buckley TC, Kaloupek DG. A meta-analytic examination of basal cardiovascular activity in posttraumatic stress disorder. Psychosom Med. 2001;63:585–594
  115. Chang L. Brain responses to visceral and somatic stimuli in irritable bowel syndrome: a central nervous system disorder?. Gastroenterol Clin North Am. 2005;34:271–279
  116. Cohen H, Kotler M, Matar MA, et al. Analysis of heart rate variability in posttraumatic stress disorder patients in response to a trauma-related reminder. Biol Psychiatry. 1998;44:1054–1059
  117. Cohen H, Neumann L, Alhosshle A, Kotler M, Abu-Shakra M, Buskila D. Abnormal sympathovagal balance in men with fibromyalgia. J Rheumatol. 2001;28:581–589
  118. Ehlert U, Gaab J, Heinrichs M. Psychoneuroendocrinological contributions to the etiology of depression, posttraumatic stress disorder, and stress-related bodily disorders: the role of the hypothalamus-pituitary-adrenal axis. Biol Psychol. 2001;57:141–152
  119. Herbert TB, Cohen S. Stress and immunity in humans: a meta-analytic review. Psychosom Med. 1993;55:364–379
  120. Larson MR, Ader R, Moynihan JA. Heart rate, neuroendocrine, and immunological reactivity in response to an acute laboratory stressor. Psychosom Med. 2001;63:493–501
  121. Lucini D, Norbiato G, Clerici M, Pagani M. Hemodynamic and autonomic adjustments to real life stress conditions in humans. Hypertension. 2002;39:184–188
  122. Zubieta JK, Chinitz JA, Lombardi U, Fig LM, Cameron OG, Liberzon I. Medial frontal cortex involvement in PTSD symptoms: a SPECT study. J Psychiatr Res. 1999;33:259–264
  123. Dantzer R. Somatization: a psychoneuroimmune perspective. Psychoneuroendocrinology. 2005;30:947–952
  124. Sternberg EM. Neural-immune interactions in health and disease. J Clin Invest. 1997;100:2641–2647
  125. Maquet P, Faymonville ME, Degueldre C, et al. Functional neuroanatomy of hypnotic state. Biol Psychiatry. 1999;45:327–333
  126. Lazar SW, Bush G, Gollub RL, Fricchione GL, Khalsa G, Benson H. Functional brain mapping of the relaxation response and meditation. Neuroreport. 2000;11:1581–1585
  127. Newberg A, Alavi A, Baime M, Pourdehnad M, Santanna J, d'Aquili E. The measurement of regional cerebral blood flow during the complex cognitive task of meditation: a preliminary SPECT study. Psychiatry Res. 2001;106:113–122
  128. Kropotov JD, Crawford HJ, Polyakov YI. Somatosensory event-related potential changes to painful stimuli during hypnotic analgesia: anterior cingulate cortex and anterior temporal cortex intracranial recordings. Int J Psychophysiol. 1997;27:1–8
  129. Rainville P, Duncan GH, Price DD, Carrier B, Bushnell MC. Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science. 1997;277:968–971
  130. Brauchli P, Michel CM, Zeier H. Electrocortical, autonomic, and subjective responses to rhythmic audio-visual stimulation. Int J Psychophysiol. 1995;19:53–66
  131. De Pascalis V, Perrone M. EEG asymmetry and heart rate during experience of hypnotic analgesia in high and low hypnotizables. Int J Psychophysiol. 1996;21:163–175
  132. De Pascalis V, Ray WJ, Tranquillo I, D'Amico D. EEG activity and heart rate during recall of emotional events in hypnosis: relationships with hypnotizability and suggestibility. Int J Psychophysiol. 1998;29:255–275
  133. Isotani T, Tanaka H, Lehmann D, et al. Source localization of EEG activity during hypnotically induced anxiety and relaxation. Int J Psychophysiol. 2001;41:143–153
  134. Jasiukaitis P, Nouriani B, Hugdahl K, Spiegel D. Relateralizing hypnosis: or, have we been barking up the wrong hemisphere?. Int J Clin Exp Hypn. 1997;45:158–177
  135. Brody AL, Saxena S, Stoessel P, et al. Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: preliminary findings. Arch Gen Psychiatry. 2001;58:631–640
  136. Rosenfeld JP, Baehr E, Baehr R, Gotlib IH, Ranganath C. Preliminary evidence that daily changes in frontal alpha asymmetry correlate with changes in affect in therapy sessions. Int J Psychophysiol. 1996;23:137–141
  137. Allen JJ, Harmon-Jones E, Cavender JH. Manipulation of frontal EEG asymmetry through biofeedback alters self-reported emotional responses and facial EMG. Psychophysiology. 2001;38:685–693
  138. Jones NA, Field T. Massage and music therapies attenuate frontal EEG asymmetry in depressed adolescents. Adolescence. 1999;34:529–534
  139. Jones NA, Field T, Davalos M. Massage therapy attenuates right frontal EEG asymmetry in one-month-old infants of depressed mothers. Infant Behav Dev. 1998;21:527
  140. Field TM. Massage therapy effects. Am Psychol. 1998;53:1270–1281
  141. Williams JD, Gruzelier JH. Differentiation of hypnosis and relaxation by analysis of narrow band theta and alpha frequencies. Int J Clin Exp Hypn. 2001;49:185–206
  142. Delmonte MM. Electrocortical activity and related phenomena associated with meditation practice: a literature review. Int J Neurosci. 1984;24:217–231
  143. Jevning R, Wallace RK, Beidebach M. The physiology of meditation: a review (A wakeful hypometabolic integrated response). Neurosci Biobehav Rev. 1992;16:415–424
  144. Kubota Y, Sato W, Toichi M, et al. Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure. Brain Res Cogn Brain Res. 2001;11:281–287
  145. Sadato N, Nakamura S, Oohashi T, et al. Neural networks for generation and suppression of alpha rhythm: a PET study. Neuroreport. 1998;9:893–897
  146. Travis F, Haaga DAF, Hagelin J, et al. Effects of transcendental meditation practice on brain functioning and stress reactivity in college students. Int J Psychophysiol. 2009;71:170–176
  147. Gemignani A, Santarcangelo E, Sebastiani L, et al. Changes in autonomic and EEG patterns induced by hypnotic imagination of aversive stimuli in man. Brain Res Bull. 2000;53:105–111
  148. Ouchi Y, Kanno T, Okada H, et al. Changes in cerebral blood flow under the prone condition with and without massage. Neurosci Lett. 2006;407:131–135
  149. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation. 1996;93:1043–1065
  150. Berntson GG, Bigger JT, Eckberg DL, et al. Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology. 1997;34:623–648
  151. Dishman RK, Nakamura Y, Garcia ME, Thompson RW, Dunn AL, Blair SN. Heart rate variability, trait anxiety, and perceived stress among physically fit men and women. Int J Psychophysiol. 2000;37:121–133
  152. Huang JL, Chiou CW, Ting CT, Chen YT, Chen SA. Sudden changes in heart rate variability during the 1999 Taiwan earthquake. Am J Cardiol. 2001;87:245–248
  153. Vrijkotte TG, van Doornen LJ, de Geus EJ. Effects of work stress on ambulatory blood pressure, heart rate, and heart rate variability. Hypertension. 2000;35:880–886
  154. Hughes JW, Stoney CM. Depressed mood is related to high-frequency heart rate variability during stressors. Psychosom Med. 2000;62:796–803
  155. Friedman BH, Thayer JF. Anxiety and autonomic flexibility: a cardiovascular approach. [republished in Biol Psychol. 1998;49:303-23] Biol Psychol. 1998;47:243–263
  156. Freeman R, Komaroff AL. Does the chronic fatigue syndrome involve the autonomic nervous system?. Am J Med. 1997;102:357–364
  157. Buch AN, Coote JH, Townend JN. Mortality, cardiac vagal control and physical training–what's the link?. Exp Physiol. 2002;87:423–435
  158. Tsuji H, Larson MG, Venditti F, et al. Impact of reduced heart rate variability on risk for cardiac events. Circulation. 1996;94:2850–2855
  159. Lane RD, Reiman EM, Ahern GL, Thayer JF. Activity in medial prefrontal cortex correlates with vagal component of heart rate variability during emotion. Brain Cogn. 2001;47:54–135
  160. Sakakibara M, Takeuchi S, Hayano J. Effect of relaxation training on cardiac parasympathetic tone. Psychophysiology. 1994;31:223–228
  161. Stefano GB, Fricchione GL, Slingsby BT, Benson H. The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide. Brain Res Brain Res Rev. 2001;35:1–19
  162. DeBenedittis G, Cigada M, Bianchi A, Signorini MG, Cerutti S. Autonomic changes during hypnosis: a heart rate variability power spectrum analysis as a marker of sympatho-vagal balance. Int J Clin Exp Hypn. 1994;42:140–152
  163. Hippel CV, Hole G, Kaschka WP. Autonomic profile under hypnosis as assessed by heart rate variability and spectral analysis. Pharmacopsychiatry. 2001;34:111–113
  164. Santarcangelo EL, Emdin M, Picano E, Raciti M. Can hypnosis modify the sympathetic-parasympathetic balance at heart level?. J Ambul Monit. 1992;5:191
  165. Carney RM, Freedland KE, Stein PK, Skala JA, Hoffman P, Jaffe AS. Change in heart rate and heart rate variability during treatment for depression in patients with coronary heart disease. Psychosom Med. 2000;62:639–647
  166. Cottingham JT, Porges SW, Richmond K. Shifts in pelvic inclination angle and parasympathetic tone produced by rolfing soft tissue manipulation. Phys Ther. 1988;68:1364–1370
  167. Field T. Massage therapy. Med Clin North Am. 2002;86:163–171
  168. Uvnas-Moberg K. Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology. 1998;23:819–835
  169. Delaney JP, Leong KS, Watkins A, Brodie D. The short-term effects of myofascial trigger point massage therapy on cardiac autonomic tone in healthy subjects. J Adv Nurs. 2002;37:364–371
  170. Haker E, Egekvist H, Bjerring P. Effect of sensory stimulation (acupuncture) on sympathetic and parasympathetic activities in healthy subjects. J Auton Nerv Syst. 2000;79:52–59
  171. Wang JD, Kuo TB, Yang CC. An alternative method to enhance vagal activities and suppress sympathetic activities in humans. Auton Neurosci. 2002;100:90–95
  172. Rush AJ, George MS, Sackeim HA, et al. Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biol Psychiatry. 2000;47:276–286
  173. Schachter SC, Saper CB. Vagus nerve stimulation. Epilepsia. 1998;39:677–686
  174. Rush AJ, Marangell LB, Sackeim HA, et al. Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biol Psychiatry. 2005;58:347–354
  175. Fallen EL, Kamath MV, Tougas G, Upton A. Afferent vagal modulation (Clinical studies of visceral sensory input). Auton Neurosci. 2001;90:35–40
  176. Chowdhary S, Vaile JC, Fletcher J, Ross HF, Coote JH, Townend JN. Nitric oxide and cardiac autonomic control in humans. Hypertension. 2000;36:264–269
  177. Anisman H, Merali Z. Cytokines, stress, and depressive illness. Brain Behav Immun. 2002;16:513–524
  178. Irwin M. Psychoneuroimmunology of depression: clinical implications. Brain Behav Immun. 2002;16:1–16
  179. Goehler LE, Gaykema RP, Nguyen KT, et al. Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?. J Neurosci. 1999;19:2799–2806
  180. Capuron L, Dantzer R. Cytokines and depression: the need for a new paradigm. Brain Behav Immun. 2003;17(suppl 1):S119–S124
  181. Rivest S. How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology. 2001;26:761–788
  182. Penninx BW, Kritchevsky SB, Yaffe K, et al. Inflammatory markers and depressed mood in older persons: results from the health, aging and body composition study. Biol Psychiatry. 2003;54:566–572
  183. Ter Horst GJ, Postema F. Forebrain parasympathetic control of heart activity: retrograde transneuronal viral labeling in rats. Am J Physiol. 1997;273(6 pt 2):H2926–H2930
  184. Gold SM, Irwin MR. Depression and immunity: inflammation and depressive symptoms in multiple sclerosis. Neurol Clin. 2006;24:507–519
  185. Heesen C, Nawrath L, Reich C, Bauer N, Schulz KH, Gold SM. Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour?. J Neurol Neurosurg Psychiatry. 2006;77:34–39
  186. Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. [erratum appears in Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:637-638] Prog Neuropsychopharmacol Biol Psychiatry. 2005;29:201–217
  187. Aronson D, Mittleman MA, Burger AJ. Interleukin-6 levels are inversely correlated with heart rate variability in patients with decompensated heart failure. J Cardiovasc Electrophysiol. 2001;12:294–300
  188. Malave HA, Taylor AA, Nattama J, Deswal A, Mann DL. Circulating levels of tumor necrosis factor correlate with indexes of depressed heart rate variability: a study in patients with mild-to-moderate heart failure. Chest. 2003;123:716–724
  189. Bernik TR, Friedman SG, Ochani M, et al. Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg. 2002;36:1231–1236
  190. Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 2000;405:458–462
  191. Floto RA, Smith KG. The vagus nerve, macrophages, and nicotine. Lancet. 2003;361:1069–1070
  192. Zeitlin D, Keller SE, Shiflett SC, Schleifer SJ, Bartlett JA. Immunological effects of massage therapy during academic stress. Psychosom Med. 2000;62:83–84
  193. Danziger N, Fournier E, Bouhassira D, et al. Different strategies of modulation can be operative during hypnotic analgesia: a neurophysiological study. Pain. 1998;75:85–92
  194. D'Esposito M, Detre JA, Aguirre GK, et al. A functional MRI study of mental image generation. Neuropsychologia. 1997;35:725–730

 This work was made possible by grants 5-T32-AT000052, 5-K30-AT000060, and 5-K07-AT002943 (A. Taylor) from the National Center for Complementary and Alternative Medicine and grant R01-MH68832 (L. Goehler) from the National Institute of Mental Health at the National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Complementary and Alternative Medicine or the National Institute of Mental Health.

PII: S1550-8307(09)00343-7

doi: 10.1016/j.explore.2009.10.004

Explore: The Journal of Science and Healing
Volume 6, Issue 1 , Pages 29-41 , January 2010

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